Poolbeg Pharma OneThree Biotech completes build and optimisation of RSV AI model

Poolbeg Pharma

Poolbeg Pharma plc (LON:POLB), a clinical stage infectious disease pharmaceutical company with a unique capital light clinical model, has announced that, further to its announcement in February 2022, Artificial Intelligence partner OneThree Biotech, Inc., has completed the build and optimisation of a tailored AI model of Poolbeg’s Respiratory Syncytial Virus human challenge data and can now commence its analysis, with results expected in Q4 2022.

Key Highlights:

Build and optimisation phase of AI model to identify RSV drug targets and treatments completed – results expected in Q4 2022
Model is uniquely tailored to use Poolbeg’s human challenge trial data of RSV
The Directors believe this is the first time that AI analysis has been used to identify new drug targets and treatments for RSV using human challenge trial data
Process will identify novel drug targets and treatments quicker and in a more cost-efficient manner than previously possible

The tailored AI model is the platform from which OneThree Biotech and Poolbeg will mine truly unique insights from human challenge trial* derived disease progression data, with the aim of identifying novel drug targets and therapies to treat RSV, a disease which is a significant public health threat.

OneThree’s clinically validated model has been optimised to harness the unique longitudinal clinical, molecular (e.g. gene and protein expression) and virological data collected during human challenge trials, and includes next generation sequencing data captured daily at all timepoints before, during and after a healthy volunteer has been infected with RSV. The controlled environment of the human challenge trial creates a uniquely clean and complete dataset which is ideally suited for AI disease modelling such as this. The research team have integrated OneThree Biotech’s world class AI, with Poolbeg’s dataset and publicly available datasets to optimise the power of the model and validate its results. The team will use the model to discover and identify the disease signatures that define RSV infection and then identify drugs that can effectively reverse those signatures with therapeutically meaningful benefits with a view to then adding such identified drugs to Poolbeg’s pipeline.

The research program will prioritise identifying drug candidates with existing Phase I safety and tolerability data generated during prior development for other disease indications. This approach significantly reduces spend and risk, with the resultant clinical development program rapidly progressing to a capital light clinical proof of concept trial. The approach is expected to generate multiple clinical stage candidates quickly and cost-effectively, in a manner consistent with Poolbeg’s model.

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Poolbeg also has an AI partnership underway with CytoReason which is focused on drug target identification for influenza infections. This is currently in the modelling stage and further updates will be provided in due course.

Jeremy Skillington, PhD, CEO of Poolbeg Pharma, said:

“OneThree Biotech’s AI model optimisation has been completed on time and is on-track to deliver results later this year. This is the first time that AI has been used to model RSV with the complete longitudinal disease data which can only be produced from human challenge trials. We are excited to see the insights into RSV that can be generated from this analysis which will help us to identify the best potential drug candidates to develop as part of our rapid, capital-light portfolio. RSV is a disease with a significant unmet medical need which causes an estimated 100,000 deaths per year in children under the age of five, we hope that the results from this programme can help us to identify an effective treatment to address this significant public health threat.”

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