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Shire Plc

Shire plc Delist during offer by Takeda Pharmaceutical Company Limited

Further to the announcement made by Shire plc (LON: SHP) on January 8, 2019, Shire today announced that, following an application by Shire, the UK Listing Authority has cancelled the listing of Shire Shares on the premium listing segment of the Official List and the London Stock Exchange has cancelled the trading of Shire Shares on the London Stock Exchange’s main market for listed securities, in each case with effect from 8.00 a.m. (London time) today, January 9, 2019. Trading of Shire ADSs has been suspended on NASDAQ and cancellation of the listing of Shire ADSs on NASDAQ is expected to take effect by 9.30 a.m. (New York time) today, January 9, 2019.

Unless otherwise defined, all capitalised terms in this announcement shall have the meaning given to them in the scheme document published on November 12, 2018 in relation to the recommended cash and share offer by Takeda Pharmaceutical Company Limited for the entire issued and to be issued share capital of Shire plc, effected by means of a scheme of arrangement under Article 125 of the Companies (Jersey) Law 1991 (as amended).