# Silence Therapeutics plc A Transformative and Highly Productive Year

- Link: https://www.directorstalkinterviews.com/silence-therapeutics-plc-transformative-highly-productive-year/412746812
- Published: 2018-03-06T07:27:10+00:00
- Author: Giles Arbor

**Silence Therapeutics plc**, (LON:SLN) a leader in the discovery, delivery and 
development of novel RNA therapeutics for the treatment of serious diseases with
unmet medical need, announces its unaudited preliminary results for the year ended
31 December 2017.

Silence Therapeutics’ international team is driving pipeline development of RNA 
interference (RNAi) therapeutics, a highly innovative, specific, new class of medicines
with life-saving potential for patients with serious and rare diseases, creating
value in tandem for our stakeholders.

**Operational Highlights**

· Generated and presented extensive, multi-faceted, pre-clinical data demonstrating
clear proof of biologic mechanism and concept for Silence’s two lead programmes 
for iron overload disorders and alcohol use disorder, planned to be in clinical 
development within 18 months.

· Data highlights included key findings in animal disease models representative 
of iron overload disorders, increasing confidence in Silence’s lead candidate SLN124,
planned to enter clinical development by the end of 2018.

· Recruited five high calibre individuals: Head of Intellectual Property, Chief 
Operating Officer, Head of Business Development and Licensing, Non-Executive Chair,
and Head of Technology Innovation – all with leadership roles at both major global
pharma and entrepreneurial biotechnology companies, as well as deep RNAi and oligonucleotide
expertise.

· During 2017 Silence commenced UK litigation action against Alnylam Pharmaceuticals
and The Medicines Company, who subsequently sought claims for revocation and declarations
of non-infringement in respect of the patent in suit. In November 2017 Silence counterclaimed
for threatened infringement of the patent in suit. It is likely that all issues 
between the parties will be heard at a trial beginning on, or around, 3 December
2018.

**Financial Highlights**

· Loss after tax of £1.6 million (2016: £8.4 million)

· Cash and cash equivalents of £42.7 million (2016: £39.0 million)

· Net cash outflow from operating activities £9.6 million (2016: £10.1 million)

· Realised gain on disposals of Arrowhead Pharmaceuticals shares £9.1 million (2016:
£nil)

· Significantly bolstered balance sheet cash with sale of Arrowhead Pharmaceuticals
shares with proceeds totalling $24.3 million.

**Post Year-End Events**

· New European patent (EP 1857547B) granted 17 January 2018 further protecting Silence’s
key siRNA chemical modifications that read widely across the RNAi industry.

· Disposal of the final portion of Arrowhead Pharmaceuticals shares in January 2018
with cumulative proceeds totaling $24.7 million and a cash balance of £43 million
as of 2 January 2018.

> **Ali Mortazavi, Chief Executive Officer of Silence Therapeutics Plc, commented:**“
> 2017 was a transformative and highly productive year for the Company. We believe
> Silence is well positioned to execute its strategy of transitioning into a drug
> development Company. We are also focused on securing strategic platform and pipeline
> deals in 2018 that validate our science and support the broadening of our pipeline
> and geographic footprint. We have established a rigorous target selection process
> to drive creation of a deep pre-clinical pipeline – crucial to the long-term business
> strategy of the Company.
> “We are excited by the potential of RNAi based therapies using our world class
> GalNAc-siRNA technology as we progress our lead asset into clinical trials, taking
> one step closer to making our therapeutic products available to patients, and 
> all the while creating value in tandem for our stakeholders. In parallel, our 
> technology innovation team continues to advance our next generation GalNAc-siRNA
> platform, and we intend to introduce this innovative technology into new pipeline
> products later in 2018. As Silence continues to adopt this growth strategy, and
> in order to continue to build value for our existing shareholders, the Company
> is currently exploring options to expand our international capital market presence,
> including the potential for a NASDAQ listing.”
> **Dr. Annalisa Jenkins, Non-Executive Chair of Silence Therapeutics, commented:**“
> I am genuinely excited about the current window of opportunity to advance our 
> leading technology platform into the clinic in the coming year. I have been highly
> impressed by the quality of the science and, specifically, the deep expertise 
> in RNAi and associated technologies. Our R&D operation in Berlin has over 15 years
> of oligonucleotide discovery research expertise in high throughput screening, 
> in vivo pharmacology and CMC (Chemistry, Manufacturing and Control). This is combined
> with remarkable people, and a culture that is dedicated to developing innovative
> new therapeutic options to change the lives of patients with serious diseases.
> I have great confidence in our ability to be a leader in the next generation of
> RNAi medicines. I believe that the team we are building will deliver a globally
> competitive and successful RNAi platform and drug development Company.”

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