# Oxford BioDynamics Plc Study published in peer reviewed journal

- Link: https://www.directorstalkinterviews.com/oxford-biodynamics-plc-study-published-peer-reviewed-journal/412753371
- Published: 2018-06-26T07:14:37+01:00
- Author: Giles Arbor

**Oxford BioDynamics Plc** (LON:OBD), a biotechnology company focused on the discovery
and development of epigenetic biomarkers based on regulatory genome architecture,
for use within the pharmaceutical and biotechnology industry, has today noted the
publication of a paper in the peer reviewed journal EBioMedicine entitled: “Initial
Identification of a Blood-Based Chromosome Conformation Signature for Aiding in 
the Diagnosis of Amyotrophic Lateral Sclerosis”.1 EBioMedicine is the open access
arm of the Lancet and Cell Publishing Groups, dedicated to the subject of translational
medicine.

· There is currently no definitive, clinically validated measure to diagnose ALS

· Diagnosis of ALS could take on average one year following onset of symptoms

· Epigenetic biomarkers represent a promising approach for definitive disease diagnosis,
with the potential to improve patient outcomes

· This represents a collaboration between Oxford BioDynamics, the University of 
Oxford, and Neurology Clinical Research Institute, Massachusetts General Hospital,
Harvard Medical School

In the study, OBD’s EpiSwitch™ platform was used to compare the genomic architecture
of healthy and Amyotrophic Lateral Sclerosis (ALS) patient samples to discover an
epigenetic biomarker, called a chromosomal conformation signature (CCS), with diagnostic
potential in ALS. The study successfully yielded a distinct CCS biomarker that was
diagnostic for ALS, demonstrating a highly promising, potential new approach to 
the diagnosis of this disease.

ALS, also known as Lou Gehrig’s disease, is a progressive, neurodegenerative disorder
characterised by muscle weakness and eventual paralysis. There is currently no definitive,
clinically validated measure to identify ALS. Doctors perform a series of exclusion
tests which often leads to a significant delay in diagnosis, averaging one year 
from the onset of symptoms. ALS is a rapidly progressing disease therefore this 
delay can have a significant clinical and lifestyle impact on patients. This delay
may also limit the recruitment of patients with early phase disease into clinical
trials.

The study represents a collaboration between Oxford BioDynamics, Nuffield Department
of Clinical Neurosciences, University of Oxford, and the Neurology Clinical Research
Institute, Department of Neurology, Massachusetts General Hospital, Harvard Medical
School.

> **Dr Alexandre Akoulitchev, Chief Scientific Officer of Oxford BioDynamics, and
> corresponding author commented:** “There is currently no definitive method for
> the differential diagnosis of ALS, which has proven to be extremely challenging
> given the very heterogeneous profiles, variable prognosis, and several potential
> sub-types of the disease. We are pleased that through our collaboration with leading
> world experts and institutions, we have successfully developed blood-based epigenetic
> biomarkers that provide new insights into disease mechanisms and have the potential
> to be used as a rapid and effective diagnostic test for this disease. We believe
> it will make an important contribution both to patient care and to therapeutic
> development.”
> **Merit E. Cudkowicz, MD, Chief of Neurology, Massachusetts General Hospital, 
> Julieanne Dorn Professor of Neurology Harvard Medical School, and co-author commented:**“
> To develop effective treatments for ALS, it is critical to both develop tools 
> to diagnose ALS earlier and understand the underlying biology. We are very excited
> to partner with colleagues at Oxford BioDynamics and in the UK to accelerate diagnosis
> and treatment.”

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