# AstraZeneca’s Lynparza demonstrates overall survival benefit in prostate cancer - Link: https://www.directorstalkinterviews.com/astrazenecas-lynparza-demonstrates-overall-survival-benefit-in-prostate-cancer/412815444 - Published: 2020-04-24T07:43:43+01:00 - Author: Amilia Stone **[AstraZeneca PLC](https://www.directorstalkinterviews.com/ftse-company/astrazeneca/azn.l)**( [LON:AZN](https://www.directorstalkinterviews.com/ftse-company/astrazeneca/azn.l)) and MSD Inc., Kenilworth, N.J., US (MSD: known as Merck & Co., Inc. inside the US and Canada) today announced further positive results from the Phase III PROfound trial of _Lynparza _(olaparib) in men with metastatic castration-resistant prostate cancer (mCRPC) who have a homologous recombination repair gene mutation (HRRm) and have progressed on prior treatment with new hormonal agent (NHA) treatments (e.g. enzalutamide and abiraterone). Results from the trial showed a statistically significant and clinically meaningful improvement in the key secondary endpoint of overall survival (OS) with _Lynparza_ versus enzalutamide or abiraterone in men with mCRPC selected for BRCA1/2 or ATM gene mutations, a subpopulation of HRR gene mutations. The Phase III PROfound trial had met its primary endpoint in August 2019, showing significantly improved radiographic progression-free survival (rPFS) in men with mutations in BRCA1/2 or ATM genes, and had met a key secondary endpoint of rPFS in the overall HRRm population. > **José Baselga, Executive Vice President, Oncology R&D, said: **“Overall survival > in metastatic castration-resistant prostate cancer has remained extremely challenging > to achieve. We are thrilled by these results for _Lynparza_ and we are working > with regulatory authorities to bring this medicine to patients as soon as possible.” > **Roy Baynes, Senior Vice President and Head of Global Clinical Development, Chief > Medical Officer, MSD Research Laboratories, said: **“_Lynparza_ has demonstrated > significant clinical benefit across key endpoints in PROfound, including overall > survival for patients with BRCA or ATM mutations, and this reinforces its potential > to change the treatment standard for patients with metastatic castration-resistant > prostate cancer. These data further support MSD and AstraZeneca’s commitment to > uncovering the ways in which _Lynparza_ can help patients impacted by cancer.” The safety and tolerability profile of _Lynparza_ was generally consistent with previous trials. The data will be presented at a forthcoming medical meeting. _Lynparza _was granted Priority Review in the US for patients with HRRm mCRPC in January 2020, with regulatory reviews ongoing in the EU and other jurisdictions. AstraZeneca and MSD are exploring additional trials in prostate cancer including the ongoing Phase III PROpel trial, with first data expected in 2021, testing _Lynparza_ as a 1st-line medicine for patients with mCRPC in combination with abiraterone acetate versus abiraterone acetate alone. **Metastatic castration-resistant prostate cancer** Prostate cancer is the second-most common cancer in men, with an estimated 1.3 million new cases diagnosed worldwide in 2018, and is associated with a significant mortality rate.^(1) Development of prostate cancer is often driven by male sex hormones called androgens, including testosterone.^(2) In patients with mCRPC, their prostate cancer grows and spreads to other parts of the body despite the use of androgen-deprivation therapy to block the action of male sex hormones.^(2) Approximately 10-20% of men with advanced prostate cancer will develop CRPC within five years, and at least 84% of these men will have metastases at the time of CRPC diagnosis.^(3) Of men with no metastases at CRPC diagnosis, 33% are likely to develop metastases within two years.^(3) Despite advances in treatment for men with mCRPC, five-year survival is low and extending survival remains a key goal for treating these men.^(3) **HRR gene mutations** HRR mutations occur in approximately 20-30% of patients with mCRPC.^(4) HRR genes allow for accurate repair of damaged DNA in normal cells.^(5,6 )HRR deficiency ( HRD) means the DNA damage cannot be repaired, and can result in normal cell death. ^(6 )This is different in cancer cells, where a mutation in HRR pathways leads to abnormal cell growth and therefore cancer.^(6 )HRD is a well-documented target for PARP inhibitors, such as _Lynparza_. PARP inhibitors block a rescue DNA damage repair mechanism by trapping PARP bound to DNA single-strand breaks which leads to replication fork stalling causing their collapse and the generation of DNA double-strand breaks, which in turn lead to cancer cell death.^(6 ) **PROfound** PROfound is a prospective, multicentre, randomised, open-label, Phase III trial testing the efficacy and safety of _Lynparza_ versus enzalutamide or abiraterone in patients with mCRPC who have progressed on prior treatment with NHA treatments( abiraterone or enzalutamide) and have a qualifying tumour mutation in BRCA1/2, ATM or one of 12 other genes involved in the HRR pathway. The trial was designed to analyse patients with HRRm genes in two cohorts: the primary endpoint was rPFS in those with mutations in BRCA1/2 or ATM genes and then, if _Lynparza_ showed clinical benefit, a formal analysis was performed of the overall trial population of patients with HRRm genes (BRCA1/2, ATM, CDK12 and 11 other HRRm genes; a key secondary endpoint). **_Lynparza_**** ** _Lynparza_ (olaparib) is a first-in-class PARP inhibitor and the first targeted treatment to block DNA damage response (DDR) in cells/tumours harbouring a deficiency in homologous recombination repair, such as mutations in BRCA1 and/or BRCA2. Inhibition of PARP with _Lynparza_ leads to the trapping of PARP bound to DNA single-strand breaks, stalling of replication forks, their collapse and the generation of DNA double-strand breaks and cancer cell death. _Lynparza_ is being tested in a range of PARP-dependent tumour types with defects and dependencies in the DDR pathway. _Lynparza_ is currently approved in a number of countries, including those in the EU, for the maintenance treatment of platinum-sensitive relapsed ovarian cancer. It is approved in the US, the EU, Japan, China, and several other countries as 1st- line maintenance treatment of BRCA-mutated advanced ovarian cancer following response to platinum-based chemotherapy. It is also approved in the US, Japan, and a number of other countries for germline BRCA-mutated, HER2-negative, metastatic breast cancer, previously treated with chemotherapy; in the EU, this includes locally advanced breast cancer. _Lynparza_ is approved in the US and several other countries for the treatment of germline BRCA-mutated metastatic pancreatic cancer. Regulatory reviews are underway in several jurisdictions for ovarian, breast, pancreatic and prostate cancers. _Lynparza_, which is being jointly developed and commercialised by AstraZeneca and MSD, has been used to treat over 30,000 patients worldwide. _Lynparza_ has the broadest and most advanced clinical trial development programme of any PARP inhibitor, and AstraZeneca and MSD are working together to understand how it may affect multiple PARP-dependent tumours as a monotherapy and in combination across multiple cancer types. _Lynparza_ is the foundation of AstraZeneca’s industry-leading portfolio of potential new medicines targeting DDR mechanisms in cancer cells. **References** _1.   Bray et al. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 68(6), pp.394-424._ _2.  Cancer.Net. (2019). Treatment of metastatic castration-resistant prostate cancer. www.cancer.net/research-and-advocacy/asco-care-and-treatment-recommendations-patients/ treatment-metastatic-castration-resistant-prostate-cancer [Last Accessed: November 2019]._ _3.   Kirby, M., 2011. Characterising the castration-resistant prostate cancer population: a systematic review. International Journal of Clinical Practice, 65(11), pp.1180- 1192._ _4.   Mateo, J, et al (2015). DNA-repair defects and olaparib in metastatic prostate cancer. New England Journal of Medicine, 373(18), pp.1697 – 1708._ _5.   Li et al. (2008). Homologous recombination in DNA repair and DNA damage tolerance. Cell Research, 18(1), pp.99-113._ _6.   Ledermann et al. (2016). Homologous recombination deficiency and ovarian cancer. European Journal of Cancer, 60, pp.49-58._ Share on: